neuroprotective peptides - PrivacyWall

https://pubmed.ncbi.nlm.nih.gov/37239313/

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Neuroprotective Peptides and New Strategies for Ischemic ... - PubMed

In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke.

https://onlinelibrary.wiley.com/doi/full/10.1111/1541-4337.12451

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Mechanisms of Neuroprotective Effects of Peptides Derived from Natural ...

Neuroprotective peptides are closely associated with protection against apoptosis, with proteins related to the cell death/survival signaling pathway, with acetylcholine activity and with inhibition of oxidative stress and inflammation.

https://www.sciencedirect.com/science/article/pii/S01969781210003...

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Whether short peptides are good candidates for future neuroprotective ...

Peptides showed antioxidant, antiinflammatory, prosurvival and neuroprotective potency as well as reduced neuropathology. Neurodegenerative diseases are a broad group of largely debilitating, and ultimately terminal conditions resulting in progressive degeneration of different brain regions.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10534798/

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Isolation, Identification, Activity Evaluation, and Mechanism of Action ...

Walnuts contain bioactive peptides with demonstrated neuroprotective effects, making them a valuable addition to the diet. We here present a comprehensive review of the various methods used to prepare, isolate, purify, and identify the neuroprotective peptides found in walnuts.

https://ifst.onlinelibrary.wiley.com/doi/full/10.1111/ijfs.14076

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Emerging roles of bioactive peptides on brain health promotion

Natural dietary bioactive compounds with potential neuroprotective and brain health benefits, including the prevention of cognitive impairment and dementia, have received increasing attention.

https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo01602a

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Multi-dimensional deep learning drives efficient discovery of novel ...

Therein, EPEVLR performed the best and can be investigated in depth as a multifunctional neuroprotective agent. This strategy will greatly improve the efficiency of screening multifunctional bioactive peptides, and it will be beneficial for the development of food functional peptides.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(00)...

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Neuroprotective peptide drug delivery and development: potential new ...

Our opinion is that we can use small peptides in the search for better neuroprotective therapeutics. Here, we review peptides as drugs: success stories, peptides in drug development and future prospects. Gonadotropin releasing hormone (GnRH; LH-RH) is used in the clinic (in a modified peptide form) as an anti-cancer and reproductive drug 3,4.

https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1541-4337.12...

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Mechanisms of Neuroprotective Effects of Peptides Derived from Natural ...

In this review, we provide an overview of the main mechanisms by which peptides derived from natural materials exhibit neuroprotective effects. We also review methods for the production of these peptides and various methods for determining their neuroprotective effects in vitro and in vivo.

https://pubmed.ncbi.nlm.nih.gov/38551052/

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Food-derived Peptides as Promising Neuroprotective Agents ... - PubMed

Fish-derived peptides have shown neuroprotective properties that reduce oxidative stress and improve motor dysfunction in Parkinson's disease models. Peptides from milk and eggs have been found to have anti-inflammatory properties that reduce inflammation and improve cognitive function in Alzheimer's disease models.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8618101/

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PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective ...

However, recent results have provided strong evidence that postsynaptic density protein-95 (PSD-95) can be exploited as an efficient target for stroke neuroprotection by strategies able to counteract excitotoxicity, a major mechanism of neuronal death after ischemic stroke.

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