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The chemical conversion of arginine to citrulline, known as citrullination or deimination. Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline.Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code.Instead, it is the result of a post-translational modification.Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes ...
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BetaThe peptide arrays each contained 75,460 17-amino-acid peptides from the following groups: citrullinated sites and their unmodified counterparts, peptides with multiple citrullination sites on the ...
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BetaCitrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. This process depends on catalytic enzymes such as peptidylarginine ... A protein undergoes many types of posttranslation modification. Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. ... utilizing the inability of trypsin to cleave after citrullinated amino acids. Journal of Proteomics & Bioinformatics. 2013;6 ...
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BetaCitrullinated proteins are implicated in autoimmune diseases. Understanding their causes and triggers is vital for developing treatments. 135 Meadowlands Pkwy, Secaucus, NJ 07094. Mon – Sat: 9:00am–18:00pm. Sunday CLOSED +1 201-393-1573. ... Citrullination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational ...
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BetaWith this, citrullinated peptides in the mixture could be identified by comparison of the peptide mass fingerprint of a modified and an unmodified version of the same sample. The reaction conditions, including pH and incubation time, were then optimized, with synthetic peptides, and validated using a digest of citrullinated fibrinogen, a protein highly implicated in citrullination-mediated disease pathogenesis . It should be emphasized that the use of an acidic reaction environment ...
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BetaThe conversion of arginine (Arg) to citrulline (Cit) changes the charge of the amino acid (Fig. 1).Arginine is strongly basic (pI . ∼ 10.76) due to the presence of a guanidino group that could easily be protonated at physiological pH.. The removal of the imino moiety (a transformation referred to as deimination) is an enzymatic reaction catalyzed by peptidylarginine deiminases (PAD).
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BetaKeywords: Immune disorders, COVID-19, Cancer, Peptidylarginine deiminases (PADs), Anti-citrullinated proteins antibodies (ACPAs), Neutrophil extracellular traps (NETs) Introduction. Post-translational modifications of histone and non-histone proteins include covalent changes taking place on the amino acid side chain leading to the addition of a chemical group, such as acetyl, methyl, phosphoryl, glycosyl, which significantly change the properties of a protein, its conformation, ...
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BetaCitrullination is a post-translational modification (PTM) that involves the hydrolysis of the positively charged guanidium group on arginine to generate a neutral urea (Fig. 1a) 1.Citrullination ...
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BetaCitrullination is the enzymatic deimination of the amino acid arginine to produce the non-essential amino acid citrulline. In the 1980s, work by Inagaki et al. demonstrated that head domain citrullination is highly destabilizing ( Figure 1 ) to vimentin, GFAP and desmin IFs, but the exact biological function of this PTM in various cells and physiological contexts has remained elusive.
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BetaBased on what is known about citrullinated proteins and RA, disease associated citrullinated proteins may be relevant for other inflammatory diseases as well. The knowledge of such specific citrullinated proteins will allow for analyzing disease pathways, unravel disease etiologies, and function as targets for novel diagnostic and therapeutic agents.
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The chemical conversion of arginine to citrulline, known as citrullination or deimination. Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline.Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code.Instead, it is the result of a post-translational modification.Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes ...
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