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https://en.wikipedia.org/wiki/Histone

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Histone - Wikipedia

In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 9 micrometers (0.09 mm) of 30 nm diameter ...

https://www.britannica.com/science/histone

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Histone | Description, Chromatin, Structure, Functions, & Facts ...

histone, type of protein that plays a critical role in the structural organization and regulation of DNA within the nucleus of eukaryotic cells. Histones were discovered in avian red blood cell nuclei by German biochemist Albrecht Kossel about 1884.. Histones are water-soluble and contain large amounts of basic amino acids, particularly lysine and arginine.

https://www.genome.gov/genetics-glossary/histone

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Histone - National Human Genome Research Institute

So histones play an important part in keeping the genome organized and wrapped neatly within a cell. Another cool thing about histone proteins is that they can be marked in ways that are like open or closed signs for a business. If the histones near a gene have certain marks, open signs, they can tell us that in a particular cell we're looking ...

https://pmc.ncbi.nlm.nih.gov/articles/PMC9720293/

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Histones: The critical players in innate immunity - PMC

Histones release and its immunostimulatory effects as DAMPs. Histones are released from tissue cells by NETosis, apoptosis, and necrosis. Extracellular histones bind to TLR to trigger intracellular MyD88-dependent signaling pathways and promote the release of cytokines and chemokines, which trigger inflammatory responses and the recruitment and migration of immune cells.

https://biomodal.com/blog/how-histone-modifications-impact-gene-r...

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How histone modifications impact gene regulation | biomodal

The structure of histones is noteworthy. Core histones possess a globular domain and N-terminal tails that exhibit high flexibility. These tails protrude from the DNA-wrapped nucleosome and are particularly important as they can undergo various chemical modifications, which have significant implications for gene regulation.

https://www.sciencedirect.com/science/article/pii/S00099120210012...

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A focus on the roles of histones in health and diseases

Histones are small basic proteins that have been studied for many years and were initially described as packaging proteins because they are responsible for compacting and organizing the DNA into structural units called nucleosomes. Histone post translational modifications play an important role in all processes requiring access to the DNA ...

https://pubmed.ncbi.nlm.nih.gov/33895124/

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A focus on the roles of histones in health and diseases

Over time, the knowledge on the role of histones has significantly changed. Initially, histones were only known as DNA packaging proteins but later, it was discovered that they act extracellularly as powerful antimicrobial agents and also as potentially self-detrimental agents. Indeed, histones were …

https://www.microscopemaster.com/histones-and-their-functions.htm...

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Histones and their Functions - MicroscopeMaster

Histones (specifically H2AX) also play an important role in DNA damage repair and chromatin remodeling. This involves the phosphorylation of serine 139 of the variant histone (In mammals). Unlike the modification of serine 10 of histone 3, this type of posttranslational modification occurs in all the phases (G1, S, G2, M) of the cell cycle to ...

https://microbiologynotes.org/histones-types-and-its-functions/

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Histones types and its functions - Microbiology Notes

It is important in the cell cycle, it is likely too be a single for condensation. Its effect in chromatin remodeling appears to be the opposite. It is of course possible that phosphorylation of different histones, or even of different amino acids add residues in one histone, has opposite effects on chromatin structure.

https://emtudodesign.com/why-does-histone-remodeling-matter.html

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Why Is Histone Remodeling Important - emtudodesign.com

Why are histones important for gene expression? Histone proteins are crucial for chromatin structure and gene regulation. They are tightly controlled during the cell cycle to ensure DNA replication is linked to histone deposition. The metabolism and regulation of canonical histone mRNAs are also regulated. In yeast, repression of histone H2B ...

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Carian berkaitan why are histones important

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Histone

In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 9 micrometers (0.09 mm) of 30 nm diameter ...

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