Histones: The critical players in innate immunity - PMC - PubMed Central (PMC)

Histones are essential components of nuclear material that help to form chromatin and act as a control switch for DNA transcription. In addition to regulating transcription, the roles of extracellular histones in the pathology of serious diseases such as stroke, sepsis, and systemic lupus erythematosus have recently attracted considerable attention.

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How histone modifications impact gene regulation | biomodal

Core histones possess a globular domain and N-terminal tails that exhibit high flexibility. These tails protrude from the DNA-wrapped nucleosome and are particularly important as they can undergo various chemical modifications, which have significant implications for gene regulation.

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Histone - Wikipedia

In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 9 micrometers (0.09 mm) of 30 nm diameter chromatin fibers.

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A focus on the roles of histones in health and diseases

Over time, the knowledge on the role of histones has significantly changed. Initially, histones were only known as DNA packaging proteins but later, it was discovered that they act extracellularly as powerful antimicrobial agents and also as potentially self-detrimental agents. Indeed, histones were …

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Histone - an overview | ScienceDirect Topics

Histones are the main protein component of chromatin and they can be divided into two major groups: core histones and linker histones. Core histones: H2A, H2B, H3, and H4 have a rather simple structural organization in which a central folded domain, the histone fold [1] , is flanked by two disordered N- and C-terminal “tails” which, in the case of H3 and H4, are very short.

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Why Is Histone Remodeling Important

Why are histones important for gene expression? Histone proteins are crucial for chromatin structure and gene regulation. They are tightly controlled during the cell cycle to ensure DNA replication is linked to histone deposition. The metabolism and regulation of ...

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What are Histones? (with pictures) - AllTheScience

Histones H1/H5 are much longer and give structural framework to the nucleosomes, much like a steel rod linking a series of disks. In human cells, if all the DNA were uncoiled and laid end to end, the strand would be about 70 inches long (1.8 m) yet only about 0.0000007 inches thick (180 nanometers).

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What Are Histones? An Overview | The Lifesciences Magazine

Histones, like skilled musicians, play a pivotal role in creating a harmonious environment where the vast stretches of DNA are packed, organized, and regulated. Understanding the nuances is essential for deciphering the complex language of chromatin and its 1.

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Histone Modifications: Insights into Their Influence on Gene Expression

This year’s Albert Lasker Basic Medical Research Award honors David Allis and Michael Grunstein for their pioneering research that highlighted the importance of histones and their post-translational modifications in the direct control of gene expression.

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Histones: The critical players in innate immunity - Frontiers

Histones are essential components of nuclear material that help to form chromatin and act as a control switch for DNA transcription. In addition to regulating transcription, the roles of extracellular histones in the pathology of serious diseases such as stroke, sepsis, and systemic lupus erythematosus have recently attracted considerable attention.

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Histone

In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 9 micrometers (0.09 mm) of 30 nm diameter chromatin fibers.

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