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BetaAMD Opteron, the first CPU to introduce the x86-64 extensions in April 2003 The five-volume set of the x86-64 Architecture Programmer's Manual, as published and distributed by AMD in 2002. x86-64 (also known as x64, x86_64, AMD64, and Intel 64) is a 64-bit extension of the x86 instruction set. It was announced in 1999 and first available in the AMD Opteron family in 2003.
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