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Figure 2. Three eukaryotic condensin complexes. Many eukaryotic cells possess two different types of condensin complexes, known as condensin I and condensin II, each of which is composed of five subunits (Figure 2). [4] Condensins I and II share the same pair of core subunits, SMC2 and SMC4, both belonging to a large family of chromosomal ATPases, known as SMC proteins (SMC stands for ...
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BetaThe substrate of lactylation is not limited to histones. Studies have shown that lactylation of PKM2 increases its pyruvate kinase activity and reduces its tetramer to dimer transition and nuclear distribution [17]. In this study, we found that PKM2 is specifically elevated in VECs exposed to hypoxia, where it apparently contributes to elevated ...
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Beta2 . ACCORDION PROTOCOL . Table of Contents Chapter Title Page . Abstract ...
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BetaIn the Pulldown assay, we observed that His-NLRP3 could be detected in the precipitate of GST-FIB magnetic beads after co-incubation with His-NLRP3, confirming their binding capability. Following TQHXD treatment, we found that the abnormal acetylation of histones H3 and H4 associated with NLRP3 after FIB treatment was reversed.
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BetaThey can be armed with histones, DNA, or different granule proteins, including myeloperoxidase (MPO) ... M2 macrophages are dominant. Interestingly, we found that SIN inhibited MSU crystal-induced M1 macrophage polarization both in vivo and in vitro, demonstrating that SIN may be particularly effective in the acute phase of gout.
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Figure 2. Three eukaryotic condensin complexes. Many eukaryotic cells possess two different types of condensin complexes, known as condensin I and condensin II, each of which is composed of five subunits (Figure 2). Condensins I and II share the same pair of core subunits, SMC2 and SMC4, both belonging to a large family of chromosomal ATPases, known as SMC proteins (SMC stands for ...
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