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Up- or Downregulation of Melanin Synthesis Using Amino Acids, Peptides ...
The major targets of amino acids, peptides, and their analogs for the control of skin pigmentation. Microphthalmia-associated transcription factor (MITF) plays a primary role in inducing gene expression of melanogenic enzymes, such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT) in response to various internal and external stimuli.
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Skin pigmentation | Coegin Pharma
NPP-4 is our skin pigmentation project. We plan to launch a self-tanning product based on NPP-4 in 2026, ... It is one of four pigmentation peptides. Subscribe. Receive press releases and reports to your e-mail. Coegin Pharma AB. Registration number 559078-0465. Address Coegin ...
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Lightening Skin Through a Melanogenesis-interrupting Peptide
Cutaneous pigmentation is determined by melanogenesis, the transfer of melanosomes to keratinocytes, and the distribution of melanin to skin, among other processes. Interrupting these would limit skin pigmentation to achieve a better skin lightening effect. Here, the authors review the biological mechanisms of melanin production, then test a peptide designed to act on them for a lightening effect.
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Peptide Design for Enhanced Anti-Melanogenesis: Optimizing ... - PubMed
Melanogenesis is a biochemical process that regulates skin pigmentation, which is crucial role in protecting against ultraviolet radiation. It is also associated with hyperpigmentation conditions such as melasma and age spots, which negatively impact aesthetics and self-confidence. Tyrosinase (TYR), …
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Full article: Peptide Design for Enhanced Anti-Melanogenesis ...
Second, peptides reduce the activity of these enzymes, lowering their capacity to catalyze the transformation of L-tyrosine substrate into melanin. In efforts to reduce melanin production at the gene transcription level, the MITF transcription factor has become the primary target of anti-hyperpigmentation peptides.
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Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular ...
In efforts to reduce melanin production at the gene transcription level, the MITF transcription factor has become the primary target of anti-hyperpigmentation peptides. 49–51 Alcalase ®-hydrolyzed sericin peptide suppresses melanogenesis by reducing MITF expression through decreased pCREB/CREB levels without affecting the GSK3β/β-catenin ...
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Peptides and Skin Health - Linus Pauling Institute
Peptide fragments of α-melanocyte stimulating hormone (MSH) are capable of stimulating production of the skin pigment melanin, potentially increasing photoprotection in the skin. (More information) Due to their influence on collagen homeostasis , bioactive peptides are being investigated for their ability to treat aged and photoaged skin.
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Antimelanogenic peptides | British Journal of Dermatology - Oxford Academic
Peptides are increasingly being used in skincare products as active ingredients and antimelanogenic (anti melanin) peptides are potentially useful for the treatment of hyperpigmentation. Alpha‐melanocyte stimulating hormone (alpha‐MSH) is a peptide that, through a complex sequence of events, is involved in the synthesis ‐ or production ‐ of melanin.
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20 Best Peptide Serums of 2024, According to Dermatologists - Prevention
Peptide serum can benefit the skin. ... Best peptide serum for hyperpigmentation. Obagi Medical Professional-C Peptide Complex . $125 at Amazon. $125 at Walmart $73 at fragrancenet.com.
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Overview of Cosmetic Peptides | Cosmetic Peptides for Skincare | Anti ...
• Copper peptides. 6.3 Hyperpigmentation and Even Skin Tone • Oligopeptide-68 • Oligopeptide-34 • Decapeptide-12. 6.4 Sensitive and Reactive Skin • Palmitoyl Tetrapeptide-7 • Acetyl Tetrapeptide-15 • Neurosensine (Acetyl Dipeptide-1 Cetyl Ester) Cosmetic peptides represent a sophisticated approach to addressing multiple skin concerns.