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thegunzone.com/22-lr-vs-22-magnumPrivate View Winner: .22 Magnum. While neither rimfire cartridge is optimal for self-defense, the .22 Magnum is more effective. The disadvantage of the .22 Magnum is that, in a short-barreled handgun, it generates considerable muzzle blast and a loud report. Recoil, as you may expect, is minimal, even in a snub-nosed revolver.